Countless peer-reviewed studies have been made on Minoxidil - one of only two licensed medications for male pattern hair loss. However, there are two forms to choose from - oral or topical - and making the choice between these now depends largely on individual preferences, effectiveness, and potential side effects. In this article, we’ll explore the key differences between these two treatment options
What is Topical Minoxidil?
Topical Minoxidil is a liquid or foam solution applied directly to the scalp. Once applied, it is absorbed through the skin, where enzymes help activate the medication to stimulate hair follicles. This method delivers Minoxidil precisely to the affected areas, making it a popular first-line treatment for hair loss.
Advantages of Topical Minoxidil
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Easy to apply and generally well tolerated.
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Considered less invasive than oral medication.
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Lower risk of systemic side effects such as bloating or heart palpitations, which can sometimes occur with oral Minoxidil.
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Available over the counter without the need for a prescription.
However, some users find that topical application can be inconvenient due to the need for regular, consistent use and the requirement to apply it to a clean, dry scalp.
What is Oral Minoxidil?
Oral Minoxidil is taken in tablet form and serves as a second-line treatment when topical Minoxidil is ineffective or unsuitable. A second-line treatment in medicine refers to a course of treatment given when the initial or "first-line" treatment fails, stops working, or causes intolerable side effects. Oral Minoxidil is a product that is actually licensed to treat bloods pressure, but it is increasingly used as an off-license alternative for hair loss at lower doses.
Advantages of Oral Minoxidil
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Expands blood vessels, increasing oxygen and nutrient delivery to hair follicles, promoting stronger hair growth.
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Suitable for individuals who lack the sulfotransferase enzyme on their scalp, which is necessary for topical Minoxidil to work. Since this enzyme is also present in the liver, oral Minoxidil can still be effective.
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An alternative for those who experience scalp irritation or allergic reactions to topical solutions.
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Requires only a once-daily dosage, removing the need for topical application and drying time.
Despite its advantages, oral Minoxidil carries a slightly higher risk of systemic side effects, such as fluid retention, dizziness, or changes in blood pressure, which should be monitored by a healthcare professional.
Can You Use Both Oral and Topical Minoxidil Together?
Some individuals consider using both forms of Minoxidil simultaneously in an effort to maximise hair regrowth. However, medical experts at Sons advise against combining the two treatments.
Oral Minoxidil is designed as a second-line treatment for those who cannot tolerate topical Minoxidil or do not respond to it. Since oral Minoxidil already works systemically to target hair regrowth, using both together may not offer significant additional benefits and could increase the risk of unwanted side effects.
Choosing Between Oral and Topical Minoxidil
When deciding between oral and topical Minoxidil, several factors should be considered:
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Topical Minoxidil is an effective, first-line treatment that is widely available and carries fewer systemic risks. However, it requires consistent application and may not work for individuals who lack the necessary scalp enzymes.
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Oral Minoxidil is an alternative for those who experience irritation from topical treatment or do not see results. It offers the convenience of a once-daily tablet but comes with a slightly higher risk of systemic side effects.
Ultimately, the choice depends on your individual response to treatment, lifestyle preferences, and medical suitability. If Topical Minoxidil is ineffective or unsuitable, Oral Minoxidil is an increasingly recognised second line alternative that can still deliver significant benefits without requiring direct scalp application.
All of our blog articles are reviewed by our Medical Director before publication.
